Universidad de Nebraska: Guanábana (Graviola): Inhibe tumores y metástasis en estudios "in vitro" y "en vivo" de células de Cáncer de Páncreas.

A continuación, se transcribe íntegro el resumen del último estudio sobre la Guanábana (llamada mundialmente "graviola"), hecho en 2012 por el Departamento de Bioquímica y Biología Molecular de la Universidad de Omaha en Nebraska (USA).

 

En él se habla de la eficacia de la Guanábana en este tipo de cáncer.

 

Cancer Lett. 2012 Oct 1;323(1):29-40. doi: 10.1016/j.canlet.2012.03.031. Epub 2012 Apr 1.

Graviola: a novel promising natural-derived drug that inhibits tumorigenicity and metastasis of pancreatic cancer cells in vitro and in vivo through altering cell metabolism.

 

Source

Department of Biochemistry and Molecular Biology, Omaha, NE 68198-5870, USA.

 

Abstract

Pancreatic tumors are resistant to conventional chemotherapies. The present study was aimed at evaluating the potential of a novel plant-derived product as a therapeutic agent for pancreatic cancer (PC). The effects of an extract from the tropical tree Annona Muricata, commonly known as Graviola, was evaluated for cytotoxicity, cell metabolism, cancer-associated protein/gene expression, tumorigenicity, and metastatic properties of PC cells. Our experiments revealed that Graviola induced necrosis of PC cells by inhibiting cellular metabolism. The expression of molecules related to hypoxia and glycolysis in PC cells (i.e. HIF-1α, NF-κB, GLUT1, GLUT4, HKII, and LDHA) were downregulated in the presence of the extract. In vitro functional assays further confirmed the inhibition of tumorigenic properties of PC cells. Overall, the compounds that are naturally present in a Graviola extract inhibited multiple signaling pathways that regulate metabolism, cell cycle, survival, and metastatic properties in PC cells. Collectively, alterations in these parameters led to a decrease in tumorigenicity and metastasis of orthotopically implanted pancreatic tumors, indicating promising characteristics of the natural product against this lethal disease.

Copyright © 2012 Elsevier Ireland Ltd. All rights reserved.

PMID:
 
22475682
 
[PubMed - indexed for MEDLINE] 
PMCID:
 
PMC3371140
 [Available on 2013/10/1]

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